A major train station in London is set to close to the public for six days.

The line connecting London Euston and Milton Keynes will be closed from Good Friday to Wednesday 8 April, with trains returning on Thursday 9 April. This is part of the investment, Network Rail said, which will take place during Easter.

The biggest upgrade is part of a wider £400m project to boost the reliability of the West Coast Main Line -Europe’s busiest mixed-use railway. “Thanks to our carefully-planned programme of £75.5m investment during this Easter alone, aimed at improving performance for both passengers and freight services, we are ensuring most services run as normal,” a message on the Network Rail website read.

The project also includes a £8.4m new track to be laid at Willesden, a £6.6m investment on a bridge in Ledburn, and a £5.8m investment in repairs to the station canopies and platform upgrades at Harrow & Wealdstone station.

A message from Network Rail read: “Passengers travelling to or from Euston should check their journeys, as there will be diversions and replacement buses.

“Elsewhere, thousands of our engineers will be delivering more than 270 other essential upgrade projects across Britain to maintain and modernise the railway, delivering a more resilient and reliable railway for the millions of passengers who use the network day in and day out.”

Jake Kelly, Network Rail regional director for North West and Central, said: “We know how important Bank Holidays are – particularly at Easter, when families and friends come together – and that’s why we work hard to keep as much of the network open as possible while carrying out these vital upgrades.

“However, Bank Holidays are also among the least busy times on the railway, and the four-day period at Easter gives us a valuable opportunity to complete projects that simply can’t be delivered during a normal weekend. This ensures we maximise the time our teams are out working on the tracks. So passengers will see some changes and it’s a good idea for people to check before they travel.”

When works will take place on the London Euston – Milton Keynes line, “services will start and end at Milton Keynes with buses to Bedford for onwards trains to London St Pancras International (Bakerloo Line and Overground trains will run between Euston and Harrow/Watford every day except Saturday and Sunday),” Network Rail added.

Other areas of the City will also be affected, as works on new switches, crossings, and structural repairs will mean reduced services between London Waterloo and Clapham Junction.

In addition to the Easter work, there will be no trains between Preston and Lancaster from 11-20 April as work continues on the West Coast Main Line. Trains will divert onto the Settle-Carlisle line and trains will run between Oxenholme to Carlisle. Bus replacement services will also be in place, Network Rail also warned passengers.